Hands On TE Biopsy for WGA-based PGD/S and Vitrification Training

jdikan — Fri, 03 Sep 2010 18:55:37 +0000

Please print the application below. Once completed, please either fax the form to 650.362.1882 or scan and email to BiopsyTraining@GeneSecurity.net.

Application

Camtasia

jdikan — Thu, 19 Aug 2010 20:46:17 +0000

Day3TestingInformation

GSN Patient Materials

jdikan — Wed, 18 Aug 2010 20:42:09 +0000

Welcome! Please call 1-877-GSN-4PGD to verify you are a current patient and to receive your password.

If you are a Partner Clinic patient Click Here

If you are an IPSO Trial patient Click Here

Protected: Genetic Counseling Materials

jdikan — Wed, 18 Aug 2010 20:15:22 +0000

Protected: Genetic Counseling Materials

jdikan — Wed, 18 Aug 2010 20:07:51 +0000

jdikan — Wed, 05 May 2010 22:24:56 +0000

About GSN

Admin — Wed, 05 May 2010 21:32:10 +0000

2010 GSN Team

The mission of GSN is to help doctors give couples the best chance of having a healthy child. Our company was formed in 2004 by a team of doctors, geneticists, statisticians, and software engineers who embarked on developing a technology, called Parental Support™, to enable highly reliable testing of multiple genes and chromosome copy number from a single cell. Today, our technology is being offered in GSN’s Partner IVF Clinics for aneuploidy screening across all 24 chromosomes in time for Day 5 transfer. Testing of single gene disorders in parallel with aneuploidy screening is currently offered under a clinical study. More information can be found on the National Institute of Health Registry website .

GSN has established relationships with the leading IVF Clinics and academic institutions across the US.

For more information please contact: info@genesecurity.net

Corporate Office Location

Silicon Valley Headquarters and Laboratory
2686 Middlefield Road
Suite C
Redwood City, CA 94063

(650)249-9090

xd_receiver.htm

jdikan — Thu, 15 Apr 2010 18:40:51 +0000

ICSI vs. IVF

jdikan — Wed, 14 Apr 2010 01:42:44 +0000

GSN recommends that you use ICSI during your cycle (intracytoplasmic sperm injection of the eggs) to eliminate the risk of sperm contamination, however, we do not require it. In several cases when ICSI has not been used we have seen triploidy ( a complete extra set of 23 chromosomes) of paternal origin. Since paternal triploidy is rare, we suspect that most of these cases are due to sperm contamination (an extra sperm outside of the embryo that contaminated the biopsy sample). GSN will notify your doctor of possible sperm contamination on the test results report, but this means that there are No Results for the tested embryo. You and your doctor can decided whether you are comfortable with this increased chance of No Results and whether or not you wish to do ICSI.

Day 3 vs. Day 5 Biopsy

jdikan — Wed, 14 Apr 2010 01:22:23 +0000

If you choose to have a day 3 biopsy you will have results on the morning of day 5, in time for a fresh transfer (no embryos will be frozen prior to transfer). Day 3 testing analyzes a single cell that has been biopsied from each embryo. Testing a single cell cannot detect or rule out the possibility of chromosome mosaicism (a condition in which some cells of an embryo have a different number of chromosomes than other cells).

If you choose to have a day 5 biopsy, a cluster of two to ten cells are removed from the mass of cells called the trophectoderm, that will become the placenta. Since embryos do not survive well outside of the mother’s uterus beyond Day 5 or 6, the embryos are frozen until results are available (1 to 2 weeks from receipt of cells). Embryos with normal chromosome results can be considered for thawing and transfer. Early data suggests aneuploidy screening of trophectoderm cells may be associated with lower mosaicism rates and higher euploidy rates (likely a product of negative selection in that aneuploid embryos are less likely to survive to Day 5) [1,2]. It is increasingly used in clinics with specialized expertise in embryo freezing and good recovery rates of frozen embryos. Not all IVF Clinics perform day 5 biopsies so please check with your IVF center if you’re interested in more information about this option.

1. Fragouli E. et al. 2008 Human Reprod 23(11):2596-608.
2. Clousten H.J. et al. 2002 Prenat Diag 22:1143-52.